既便于病程纵向对比复盘，也让每一步诊疗都有据可查。

今日讨论：你会因为“天然雌激素”这几个字下单吗？ 作者：谷传玲、薛庆鑫 编辑：小薛营养师 封面图/文图：AI制作 参考文献： [1]Marrian GF, Haslewood GA. Equol, a new inactive phenol isolated from the ketohydroxyoestrin fraction of mares' urine. Biochem J. 1932;26(4):1227-1232. doi:10.1042/bj0261227 [2] Setchell KDR, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol—a clue to the effectiveness of soy and its isoflavones. J Nutr. 2002;132(12):3577-3584. doi:10.1093/jn/132.12.3577 (PMID: 12468591) [3] Setchell KDR, Cole SJ. Method of defining equol-producer status and its frequency among vegetarians. J Nutr. 2006;136(8):2188-2193. doi:10.1093/jn/136.8.2188 (PMID: 16857839) [4] Song KB, Atkinson C, Frankenfeld CL, et al. Prevalence of daidzein-metabolizing phenotypes differs between Caucasian and Korean American women and girls. J Nutr. 2006;136(5):1347-1351. doi:10.1093/jn/136.5.1347 (PMID: 16614428) [5] Aso T, Uchiyama S, Matsumura Y, et al. A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health (Larchmt). 2012;21(1):92-100. doi:10.1089/jwh.2011.2753 (PMID: 21992596) [6]Daily JW, Ko BS, Ryuk J, Liu M, Zhang W, Park S. Equol Decreases Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2019;22(2):127-139. doi:10.1089/jmf.2018.4265 [7]李海亮,邓颖,王欣,等.肠道微生物代谢产物—S-雌马酚与人类健康关系研究进展[J].中国微生态学杂志,2018,30(03):362-367.DOI:10.13381/j.cnki.cjm.201803027. [8] Ahuja V, Miura K, Vishnu A, et al. Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men. Br J Nutr. 2017;117(2):260-266. doi:10.1017/S000711451600458X (PMID: 28205492) [9] Zhang X, Veliky CV, Birru RL, Barinas-Mitchell E, Magnani JW, Sekikawa A. Potential Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases—From Molecular Mechanisms to Studies in Humans. Nutrients. 2021;13(11):3739. doi:10.3390/nu13113739 (PMID: 34835997) [10]Sekikawa A, Weaver A, Mroz K, et al. S-Equol as a Gut-Derived Phytoestrogen Targeting Estrogen Receptor β: A Promising Bioactive Nutrient for Bone Health in Aging Women and Men: A Narrative Review. Nutrients. 2025;17(24):3962. Published 2025 Dec 18. doi:10.3390/nu17243962 [11]Perez-Cornago A, Appleby PN, Boeing H, et al. Circulating isoflavone and lignan concentrations and prostate cancer risk: a meta-analysis of individual participant data from seven prospective studies including 2,828 cases and 5,593 controls. Int J Cancer. 2018;143(11):2677-2686. doi:10.1002/ijc.31640 [12]张健.S-雌马酚抗乳腺癌作用及机制研究[D].西南大学,2020.DOI:10.27684/d.cnki.gxndx.2020.004782. [13]Ward H, Chapelais G, Kuhnle GG, et al. Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study. Breast Cancer Res. 2008;10(2):R32. doi:10.1186/bcr1995 [14]Liu B, Qin L, Liu A, et al. Prevalence of the equol-producer phenotype and its relationship with dietary isoflavone and serum lipids in healthy Chinese adults. J Epidemiol. 2010;20(5):377-384. doi:10.2188/jea.je20090185 [15]Jackson RL, Greiwe JS, Desai PB, Schwen RJ. Single-dose and steady-state pharmacokinetic studies of S-equol, a potent nonhormonal, estrogen receptor β-agonist being developed for the treatment of menopausal symptoms. Menopause. 2011;18(2):185-193. doi:10.1097/gme.0b013e3181f8a18a. [16] Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Natural S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese women: a pilot randomized, placebo-controlled trial. Menopause. 2011;18(5):563-574. doi:10.1097/gme.0b013e3181f85aa7.当下正值杨梅上市的季节，它是咱们国家亚热带的特色水果，在国外很少种植。